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I will assume you mean the nonce that bitcoin miners iterate. Depending on e.g. wallet software other salts or nonces may be involved. That nonce is only used once, because every miner1 will be hashing a different transaction block (hash) – one which sends the reward for solving the proof of work to their address. A miner could reuse a nonce but they would ...


I would explore the GPU option before spending money on specialized hardware. I have done something similar using CUDA where I was doing many ECC operations in parallel. The GPU was about 30x - 50x faster than the CPU. You could probably hash the data on the CPU and then use the GPU for the RSA exponentiation.

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