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ISAAC can have up to $2^{2^{13}}$ bit keys and has no known attacks better than at least $4.67⋅10^{1240} > 2^{4121}$ complexitiy (assuming that the initial state is chosen uniformly at random). It is a stream cipher, but this can still be used for AEAD. While old and with only minimal cryptanalysis, the best known attack is still much harder than the ...

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