Most PRNGsSome CSPRNGs accept a constant width seed. That means they could only be used as randomness extractors for that input size; no less, no more. For example, AES-128 CTRCTR_DRBG CSPRNG (from 800-90A) would only accept 256 bits of seed for the key and initial vector in total.
Further, if the input is not fully random (as you'd expect with a randomness extractor), they can be vulnerable to related-key attacks. When used as a random number generator the key is usually assumed to be uniformly random – e.g. the CSPRNG I mentioned aboveAES-128 CTR_DRBG requires exactly 256 bits of entropy in the seed, unless a KDF is used for randomness extraction.