As an example could be XTS with a 512-bit key that treats the key as one 128-bit key and one 348-bit key.
As to why I'm asking it's because XTS runs on one large key that it treats like two keys. Currently, the XTS splits the key in half producing(if we were to use the example above) 2^256 + 2^256(2.3158418e+77) possibilities but if it were to split it differently it could produce 2^128 + 2^348(5.733747e+104) possibilities.
As to why XTS is a thing it's because it is currently the best mode for full drive encryption