In an one-time pad scheme, $s \oplus m$ is uniformly random for any $m \in \{ 0,1 \}^\ell$ if $s$ is uniform in $\{ 0,1 \}^\ell$. By the security of PRF, it seems to be secure to replace the truly uniform string $s$ with the output $F_k(r)$ of a PRF $F: \{ 0,1 \}^\kappa \times \{ 0,1 \}^\ell \rightarrow \{ 0,1 \}^\ell$. Let us consider a case where $r$ can only be chosen from a small range with limited entropy (e.g., $\{ 0...00,0...01 \}$ with $\ell - 1$ leading zeros). Is it possible for an adversary who has no idea about $k$ to distinguish between the one-time pad $F_k(r) \oplus m$ and a truly random string? If possible, how does the entropy of $r$ influence the advantage of such an adversary?
Many thanks for any help.