In multivariate schemes, the secret key is a ``simple'' multivariate polynomial with some structure. The public key is obtained by wrapping the secret key in random linear maps. The resulting multivariate polynomial representation is very dense and unstructured to anyone without the secret key, meaning that any possible monomial would occur with high probability (depending on the field size). That means, storing $n$ such polynomials would require $O(n\binom{n}{d})\approx n^{d+1}$ coefficients, where $n$ is the number of variables / outputs and $d$ is the degree. The same value determines time complexity of encryption, as one has to go through all the coefficients in the public key to compute the ciphertext.
As you can see, degree 2 schemes already have cubic complexity in the number of variables.