Adiantum<sup>1</sup> is a wide-block cipher built out of ChaCha12, NH-Poly1305, and&mdash;for only a small part of the computation&mdash;AES.
Being a wide-block cipher, Adiantum can encrypt, for example, entire 512-byte or 4096-byte disk sectors at a time.
For each disk sector, Adiantum calls the AES permutation only once, so even constant-time software AES takes a small fraction of the Adiantum computation time.

Adiantum is reasonably fast, many times faster than constant-time software AES-XTS or AES-CBC on many machines, and provides better security; see the paper for performance measurements and security theorem.

Android and NetBSD have adopted Adiantum for disk encryption on machines without hardware AES acceleration.<sup>2,3,4</sup>
In the NetBSD kernel, AES is computed using constant-time software on machines without hardware AES acceleration.<sup>4,5</sup>

<i>Caveat: Adiantum is designed for disk encryption, which reuses the same key over a long period of time for many sectors being rewritten.
Unlike the ChaCha or Poly1305 components it uses, Adiantum incurs a high cost to changing keys&mdash;not relevant to disk encryption.
So it's not very general-purpose.
(The same authors proposed HPolyC, at lower throughput but cheaper key agility by using just Poly1305 and not NH.)
The disk encryption threat model is also very weak&mdash;it is only designed to protect secrets against theft or recycling of your disk, so it does nothing to detect forgery.</i>

(Disclosure: I wrote NetBSD's Adiantum and AES code and made the proposal to adopt Adiantum.)

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<sub><sup>1</sup> Paul Crowley and Eric Biggers, Adiantum: length-preserving encryption for entry-level processors.  IACR Transactions on Symmetric Cryptology, 2018(4), 39&ndash;61. <br/> https://doi.org/10.13154/tosc.v2018.i4.39-61</sub>

<sub><sup>2</sup> Paul Crowley and Eric Biggers, Introducing Adiantum: Encryption for the Next Billion Users.  Google Security Blog, 2019-02-07. <br/> https://security.googleblog.com/2019/02/introducing-adiantum-encryption-for.html</sub>

<sub><sup>3</sup> NetBSD Manual Pages: cgd(4) -- cryptographic disk driver.  NetBSD 10.0_BETA, August 16, 2020. <br/> https://man.netbsd.org/NetBSD-10.0-STABLE/cgd.4</sub>

<sub><sup>4</sup> Taylor R Campbell, AES leaks, cgd ciphers, and vector units in the kernel.  NetBSD tech-kern mailing list, 2020-06-17, message-id &langle;[email protected]&rangle;. <br/> https://mail-index.netbsd.org/tech-kern/2020/06/18/msg026505.html</sub>

<sub><sup>5</sup> Taylor R Campbell, Rework AES in kernel to finally address CVE-2005-1797.  NetBSD commit: src/sys, 2020-06-29. <br/> https://mail-index.netbsd.org/source-changes/2020/08/14/msg120525.html</sub>