So, the effect of the unknown key $k$ is reflected in the $2n-1$bit output of $F(k,x)$ and it can be ignored.
A random uniform sequence $r$ of length $2n-1$ with equally likely zeroes and ones has Hamming weight distributed according to $\mathbb{Bin}(2n-1,1/2)$ while your $F_2(k,x)$ assuming $F(k,x)$ is random has Hamming weight distributed according to $\mathbb{Bin}(2n-1,1/4).$
Define the treshold below which you will declare non-random as $t=3(2n-1)/8$ (the midpoint between $(2n-1)/2$ and $(2n-1)/4$; this can be made more precise by carefully considering the flawed $F_2(k,x)$ distribution). The point is that with overwhelming probability a random string will have Hamming weight above $t.$
We use the simplified Chernoff bound on Binomial tails (see Wikipedia). For independent random variables $X_1,\ldots,X_m$ in $\{0,1\}$ with
$$
X=X_1+\cdots+X_m
$$
and mean $\mathbb{E}[X]=\mu,$ we have
$$
Pr[X\leq (1-\delta)\mu]\leq \exp[-\delta^2 \mu/2].
$$
Here, $\mu=(2n-1)/2,$ and $\delta=1/8.$ This gives the upper bound
$$
Pr[\mathrm{HammingWeight}[r]\leq t]
\leq \exp[-(1/8)^2 (2n-1)/4]=\\
=\exp[-(2n-1)/256]\approx \exp[-n/128].
$$
This is falling exponentially and can be made arbitrarily small by choosing $n$ large enough. For example if $n=2^{12},$ the upper bound is roughly
$$\exp[-2^{12-7}]=\exp[-2^5]\approx 2^{-32 /\ln 2}=2^{-46}.$$