What you ask for is a RNG to produce some output which another RNG will use as seed. This looks quite overly complex...
The point of the seed is to be unknown to the attacker: the seed data should be such that "trying out" possible seed values should not match the actual seed except with negligible probability. With a 64-bit seed, even if the seed is "perfect" (chosen totally randomly and uniformly among the $2^{64}$ possible seed values), an attacker trying possible seed value still has a $2^{-64}$ probability of finding the correct seed at each try, and that's a bit high for comfort. We usually prefer attack probabilities of $2^{-128}$ or less. Regardless of how you generate your 64-bit seed, how you then expand that 64-bit seed into whatever ISAAC requires, and whether ISAAC is good or not, your security will never be higher than that provided by a 64-bit seed.
How ISAAC is supposed to be seeded (with what, under which properties) is not clear; the ISAAC author himself says:
I provided no official seeding routine because I didn't feel competent to give one. Seeding a random number generator is essentially the same problem as encrypting the seed with a block cipher. ISAAC should be initialized with the encryption of the seed by some secure cipher. I've provided a seeding routine in my implementations, which nobody has broken so far, but I have less faith in that initialization routine than I have in ISAAC.
Come to think of it, this is a bit scary comment. Are you sure you want to trust the security of a system, a part of which being deemed by the author himself as being not trustworthy ?
And more generally, ISAAC was designed at a time where the competition was RC4, a generator with known biases, and not that fast. Science has improved since. See the eSTREAM project: this is the result of a kind of open competition, where cryptographers proposed new stream cipher designs, and tried to break the proposed designs. The resulting "portfolio" consists in the designs which resisted cryptanalysis, and offer good performance. The good thing about these stream ciphers is that they work with keys of reasonable size, with no underspecified part as the seeding in ISAAC. For instance, consider Sosemanuk: it accepts a key of 1 to 256 bits, and a 128-bit IV, and produces pseudo-random bytes at an reasonably high speed (it should be competitive with ISAAC, possibly even a tad faster).
This would lead to the following design:
- Accumulate your source entropy in a buffer. It does not really matter how you encode each metric, as long as you do not lose information.
- Hash the whole buffer with a secure hash function, preferably SHA-256. This results in a 256-bit value.
- Use the 256-bit value as key for Sosemanuk (the IV can be 0). Produce random bytes. Enjoy.
- (Alternatively, use the Sosemanuk output as seed for ISAAC, if you really need, for administrative reasons, to use ISAAC. But the under-specification of the seeding process could trigger weaknesses, so I would not recommend it at all.)
Note that entropy gathering is a subtle thing. MAC address and system clock, for instance, are really bad entropy sources because they can be observed by attackers: the system clock is close to the current time, which (by definition) is public data, and the machine will write its MAC address on every ethernet frame it emits. Entropy is good only insofar as it is unknown to the attacker. The good thing about SHA-256 is that it does not matter if some of your entropy is bad, as long as there is also some good entropy somewhere in your buffer. Still, you are warmly encouraged to use as entropy sources the services specifically offered by the operating system to that effect (it is called CryptGenRandom()
on Windows, /dev/urandom
on Unix-like systems and MacOS X): since the OS directly manages the hardware, it is in ideal position to gather entropy from hardware sources.